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Depigmentation therapy (Cosmelan, Dermelan)

Depigmentation therapy (Cosmelan, Dermelan)

Treatment overview

Human skin owes its colour to a pigment - melanin. Melanin is produced in melanocytes, chromocytes located in the epidermis. These cells have special structures referred to as melanosomes where, after numerous metabolic transformations, melanin is produced. It plays an important and useful role, involving protection of the skin against harmful impact of ultraviolet radiation. Excessive accumulation of melanin causes occurrence of brown or russet spots, especially in uncovered areas such as the face, cleavage, hands and arms. Factors which support occurrence of pigment spots is the skin aging process resulting from excessive exposition to sunlight, certain individual predisposition and the influence of hormones (pregnancy, contraceptives).

Not only does the COSMELAN® treatment enable effective removal of pigment spots, but it restores smoothness and radiance to the skin. The Cosmelan treatment programme is tailored to meet the individual needs of the patient and the patient’s skin phototype. The main indication is elimination of spots with a hormonal background (melasma, chloasma) and those caused by sunlight.

Dermamelan contains more active ingredients than Cosmelan and it contains salicylic acid (which is not contained in Cosmelan). The difference in composition may suggest greater suitability of Dermamelan for sebaceous skin, but Cosmelan also works well in connection with this kind of skin.

Is this a painful treatment?

During the first 2 days after the treatment and in case of very sensitive skins, the skin may be reddened. This is a normal reaction. You may also observe a feeling of tension and burning. To reduce the skin discomfort sensation, you may increase frequency of soothing cream application.

When does the effect appear and how long does it last?

Skin condition improves one week after the beginning of the treatment. Depending on the skin type, treatment proceeds at a different pace. In case of dark skin, spots disappear after 8-10 days. In case of patients with fair skin – blondes and brown-haired persons with light coloured eyes – disappearance of spots is observed between days 8 and 21. In 99% cases, intensity of spot colour is reduced by 95%. Although the discolourations virtually disappear, one can sometimes notice a shadow at their former location.

Therapy schedule

Stage I is performed at the clinic and it involves application of Cosmelan 1 mask onto the skin by a doctor. The mask remains on the skin for a few hours, after which it is washed off by the patient at home. The mask application time is 5-10 hours and it is determined by the doctor depending on the skin type.

Stage II constitutes continuation of the therapy at home, using Cosmelan 2 cream. It allows sustaining and deepening the treatment effect. Continuation of the treatment at home guarantees durable results of the therapy initiated at the clinic and allows effective removal of discolourations.

Although noticeable improvement of skin condition and brightening of the discolourations will be visible towards the end of the first week, the therapy must be continued for at least 3 months. If shortened, the previous condition may return and the therapy may need to be repeated.

One-off DERMAMELAN® treatment allows achievement of effects similar to effects achieved after the Cosmelan treatment, with higher safety profile.

Post-treatment recommendations

Treatment continuity is crucial. If treatment with the preparation is interrupted, discolourations may reappear as the therapy does not eliminate the hyperpigmentation tendency, but only interrupts this phenomenon. After the end of the therapy, the patient needs to remember to apply appropriate SPF 50 sun protection products. In fact, if proper protection is not ensured, and the body demonstrates a tendency to develop discolourations – the spots may appear again.

Contraindications and adverse effects

  • Skin allergies
  • Herpes
  • Treatment with vitamin A derivatives
  • Pregnancy and lactation
  • Bacterial infections
  • Viral infections
  • Hypersensitivity to light
  • Tendency to develop keloids

The adverse effects are usually foreseeable, moderate and temporary. These usually involve exfoliation of the skin for approximately 7-10 days, redness, tenderness, intensified acne lesions, post-treatment discolourations in case of patients who do not observe the sun protection rules.


  • Discolourations
  • Chloasma (hormonal discolourations)
  • Freckles
  • Old age spots
  • Spots caused by the sun
Klinika Ambroziak

al. Gen. W. Sikorskiego 13/U1
02-758 Warszawa

Mon-ri: 10:00-18:00
Sat: 10:00-18:00

Szpital Ambroziak

ul. Młynarska 2a
05-500 Piaseczno

Mon-Fri: 10:00-20:00
Sat: Closed

Szpital Ambroziak

Wilanów, ul. Kosiarzy 9 A
02-953 Warszawa

Mon-Fri: 9:00-20:00
Sat: Closed